Overview: CJC-1295 with DAC is a long-acting synthetic analog of Growth Hormone Releasing Hormone (GHRH 1–29), developed to stimulate the endogenous release of growth hormone (GH) and increase circulating insulin-like growth factor 1 (IGF-1) levels. The incorporation of Drug Affinity Complex (DAC) technology extends the peptide’s half-life from minutes to several days, making it a prominent tool in preclinical studies of endocrine function, muscle regeneration, metabolism, and anti-aging interventions.
CJC-1295 with DAC binds to GHRH receptors on the anterior pituitary, promoting natural pulsatile GH secretion that mimics the body’s physiological rhythm. Unlike exogenous GH administration, which may disrupt feedback loops, CJC-1295 enhances the body’s own GH production while preserving regulatory balance.
The DAC modification allows CJC-1295 to bind covalently to albumin, protecting it from enzymatic degradation and renal clearance. This results in a prolonged half-life of 5.8 to 8.1 days, enabling once- or twice-weekly dosing in experimental models.
This sustained GH stimulation supports:
Increased IGF-1 production
Enhanced protein synthesis and collagen formation
Fat metabolism (lipolysis)
Support for lean body mass preservation and cellular repair
Preclinical Studies:
In healthy adult models, CJC-1295 with DAC produced up to 2–3 fold increases in GH and IGF-1 levels for up to 14 days post-injection.
Research suggests it may promote muscle regeneration, bone mineral density retention, and neuroendocrine function.
Animal studies have also shown improved lipid profiles, immune modulation, and support for age-related endocrine decline.
Intended Use:
The information provided on this site is intended exclusively for educational and research purposes and should not be interpreted as medical guidance.
Research compounds, including CJC-1295 DAC, are designed solely for laboratory investigation by qualified professionals and are not intended for human use or consumption.
The statements presented here have not been evaluated by the U.S. Food and Drug Administration, and the products discussed are not intended to diagnose, treat, cure, or prevent any disease.
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