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GHK-CU (100mg)

GHK-CU (100mg)

$75.00 USD
$75.00 USD
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GHK-Cu is a naturally occurring copper-binding tripeptide composed of glycyl-L-histidyl-L-lysine, found in human plasma, saliva, and urine. Discovered in 1973 by Dr. Loren Pickart, GHK-Cu has been widely studied for its tissue remodeling, wound healing, anti-inflammatory, and anti-aging properties. It plays a key role in skin regeneration, hair growth, and epigenetic regulation of gene expression, particularly in aging and damaged tissues.

Its high affinity for copper ions gives it a unique ability to modulate oxidative stress, enhance collagen synthesis, and activate pathways involved in cell proliferation and repair.

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PubChem Information

https://pubchem.ncbi.nlm.nih.gov/compound/71587328

What is GHK-CU?

  • Mechanism of Action:

    GHK-Cu exerts biological effects through multiple pathways involving copper transport, gene modulation, and growth factor signaling:

    • Copper transport and stabilization: Acts as a carrier of divalent copper ions (Cu²⁺), facilitating their bioavailability for enzymatic processes involved in healing and regeneration.
    • Stimulation of extracellular matrix (ECM) synthesis: Enhances collagen, elastin, and glycosaminoglycan production, supporting structural integrity of skin and connective tissue.
    • Antioxidant and anti-inflammatory effects: Reduces reactive oxygen species (ROS), inhibits TNF-α, and downregulates NF-κB signaling.
    • Gene expression modulation: Influences over 4,000 human genes, upregulating those involved in tissue repair and downregulating those linked to inflammation and cancer.
    • Wound healing activation: Promotes angiogenesis, increases keratinocyte and fibroblast migration, and accelerates re-epithelialization.

  • Preclinical and Clinical Studies:

    • Wound and skin healing: GHK-Cu has been shown to accelerate wound closure, reduce scarring, and improve tissue elasticity in both animals and human skin explants.
    • Hair growth: Topical and injectable GHK-Cu promotes hair follicle stimulation, increases hair shaft size, and reduces follicular miniaturization in models of androgenic alopecia.
    • Anti-aging and dermal regeneration: Improves skin density, tightness, and appearance of wrinkles by increasing dermal fibroblast activity and ECM production.
    • Anti-inflammatory effects: Inhibits cytokines and metalloproteinases (MMPs), reducing oxidative tissue damage.
    • Epigenetic rejuvenation: Demonstrates gene-level reprogramming associated with youthful cellular behavior, offering potential in anti-aging therapeutics.

  • Intended Use:

    • The information provided on this site is intended exclusively for educational and research purposes and should not be interpreted as medical guidance.
    • Research compounds, including GHK-CU, are designed solely for laboratory investigation by qualified professionals and are not intended for human use or consumption.
    • The statements presented here have not been evaluated by the U.S. Food and Drug Administration, and the products discussed are not intended to diagnose, treat, cure, or prevent any disease.