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IGF-1 LR3 (1mg)

IGF-1 LR3 (1mg)

$75.00 USD
$75.00 USD
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Overview:

IGF-1 LR3 is a recombinant analog of human Insulin-Like Growth Factor 1 (IGF-1), a peptide hormone primarily produced in the liver in response to growth hormone (GH) stimulation. IGF-1 plays a central role in muscle growth, repair, and metabolic regulation.

The “Long R3” modification enhances its biological activity and resistance to IGF-binding proteins (IGFBPs), resulting in greater potency and a longer half-life compared to native IGF-1. This makes IGF-1 LR3 a powerful tool in muscle physiology, cell regeneration, and anti-aging research.

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What is IGF-1 LR3?

  • Mechanism of Action:

    IGF-1 LR3 binds to the IGF-1 receptor (IGF1R) on target cells and triggers signaling cascades responsible for growth, survival, and anabolism:

    • PI3K/AKT Pathway Activation: Promotes cell survival, protein synthesis, and glucose uptake.
    • MAPK Pathway Activation: Stimulates cell proliferation and tissue repair.
    • Resistance to IGFBPs: The LR3 variant reduces binding to IGFBPs, leading to greater free-circulating IGF-1 and enhanced bioavailability.
    • Anabolic Environment: Supports satellite cell proliferation, muscle hypertrophy, and tissue remodeling.

  • Preclinical and Clinical Studies:

    • Muscle Regeneration: Promotes muscle fiber repair, hypertrophy, and satellite cell activation in both young and aged animal models.
    • Neuroprotection: May enhance neuronal survival, plasticity, and cognitive function, especially in aging and injury contexts.
    • Wound Healing: Enhances collagen production, angiogenesis, and epidermal regeneration.
    • Metabolic Impact: Improves insulin sensitivity, supports glucose uptake, and regulates lipid metabolism.
    • Bone Health: Stimulates osteoblast activity and may assist in maintaining bone density.

  • Intended Use:

    • The information provided on this site is intended exclusively for educational and research purposes and should not be interpreted as medical guidance.
    • Research compounds, including IGF-1LR3, are designed solely for laboratory investigation by qualified professionals and are not intended for human use or consumption.
    • The statements presented here have not been evaluated by the U.S. Food and Drug Administration, and the products discussed are not intended to diagnose, treat, cure, or prevent any disease.