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Melanotan (10mg)

Melanotan (10mg)

$45.00 USD
$45.00 USD
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Overview: 

Melanotan refers to synthetic analogues of the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH), designed to interact with melanocortin receptors involved in pigmentation, metabolic regulation, inflammation, and neuroprotection. Research on Melanotan compounds (including Melanotan-1) has shown their ability to enhance melanin production and support photoprotection, while also providing a model for studying how melanocortin pathways influence diverse biological processes such as cardiovascular function, neuroinflammation, and energy metabolism.

Although originally investigated for sunless tanning, Melanotan’s receptor selectivity has broadened its relevance across multiple scientific disciplines. Scientific exploration has expanded Melanotan’s potential into areas including skin-damage prevention, neurodegenerative disease research, inflammatory disorders, metabolic studies, cardiovascular resilience, and stroke recovery. Its selective activity across MC1R, MC3R, MC4R, and MC5R provides a valuable tool for understanding melanocortin signaling and how modulation of these receptors may influence pigmentation, inflammation, appetite regulation, lipid oxidation, and neuroprotection. All research is preclinical or investigational, with ongoing clinical interest noted for specific dermatological applications

PubChem Information

https://pubchem.ncbi.nlm.nih.gov/compound/16197727

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What is Melanotan?

  • Mechanism of Action:

    • Synthetic analogue of α-MSH, designed to bind melanocortin receptors involved in pigmentation and cellular signaling
    • Strong agonist of MC1R, initiating melanin production and photoprotective pigmentation
    • Activity at MC3R, MC4R, and MC5R contributes to effects on metabolism, inflammation, and neural signaling
    • Promotes eumelanin production, increasing resistance to UV-induced skin damage
    • Modulates central nervous system pathways, including neurotrophic factor expression and synaptic signaling
    • Influences fatty-acid oxidation and metabolic energy balance through MC5R-mediated pathways
    • Demonstrated ability to support anti-inflammatory actions, including T-cell modulation and neuroinflammatory response reduction

  • Preclinical Studies:

    Pigmentation & Photoprotection

    • Enhances tanning response and reduces UV-induced skin injury; subjects require significantly less UV exposure to tan and maintain pigmentation longer
    • Investigated clinically for erythropoietic protoporphyria, polymorphic light eruption, and actinic keratosis
    • Studied in combination with UVB for vitiligo, supporting melanocyte proliferation and repigmentation responses

    Neuroprotection & Neurodegenerative Research

    • Reduces amyloid-beta plaque burden, improves synaptic function, and supports cognitive performance in Alzheimer’s disease mouse models
    • Enhances BDNF expression and supports astrocyte-mediated neuronal protection
      Improves neurological recovery after stroke, even when administered hours after ischemic events

    Inflammatory & Autoimmune Disorders

    • Demonstrated protection in models of multiple sclerosis, preventing demyelination and supporting neuronal signaling recovery
    • Reduces inflammatory processes in uveitis, with both systemic and ocular administration showing benefit

    Cardiovascular & Circulatory Function

    • May protect against hypertension, modulating blood pressure responses without causing hypotension in normotensive subjects
    • Improves outcomes during cardiac arrest, including survival and restoration of circulatory stability

    Metabolic & Fat-Oxidation Research

    • Stimulates fatty-acid oxidation through MC5R, shifting cells from fat-storage to fat-burning states
    • Provides a research model for studying obesity, lipid metabolism, and energy-expenditure pathways

  • Intended Use:

    • The information provided on this site is intended exclusively for educational and research purposes and should not be interpreted as medical guidance.
    • Research compounds, including Melanotan, are designed solely for laboratory investigation by qualified professionals and are not intended for human use or consumption.
    • The statements presented here have not been evaluated by the U.S. Food and
      Drug Administration, and the products discussed are not intended to diagnose,
      treat, cure, or prevent any disease.