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MGF (2mg)

MGF (2mg)

$35.00 USD
$35.00 USD
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Overview:

MGF (Mechano Growth Factor) is a naturally occurring splice variant of IGF-1 (Insulin-Like Growth Factor-1) that is rapidly expressed in skeletal muscle in response to mechanical overload or damage. It plays a pivotal role in muscle repair, regeneration, and hypertrophy, particularly by activating satellite cells and stimulating muscle fiber growth.

Synthetic MGF, commonly studied as PEG-MGF (pegylated MGF) is designed to mimic the natural peptide while prolonging its half-life, making it useful in muscle physiology research and regenerative medicine.

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What is MGF?

  • Mechanism of Action:

    MGF’s function centers around its autocrine and paracrine signaling in muscle tissue:

    • Splice Variant Activity: MGF differs from IGF-1 in its E-domain sequence, allowing it to act locally and rapidly after muscular stress.
    • Satellite Cell Activation: Promotes proliferation of muscle stem cells, which are crucial for tissue repair and hypertrophy.
    • Myogenesis and Regeneration: Increases protein synthesis, muscle fiber recruitment, and muscle cell differentiation.
    • Neuroprotection and Cardioprotection: Shown to offer protective effects in neurons and cardiac cells under stress or injury.

  • Preclinical and Clinical Studies:

    • Muscle Growth and Repair: MGF promotes muscle mass accrual, especially in damaged or atrophied muscles, making it a candidate for sarcopenia or cachexia models.
    • Injury Recovery: Enhances tissue healing post-trauma or surgery by accelerating muscle stem cell activation.
    • Neuroprotective Effects: Demonstrated ability to prevent apoptosis in neurons and may play a role in motor neuron survival.
    • Cardiovascular Support: Improves cardiac function post-infarction and may support vascular repair mechanisms.

  • Intended Use:

    • The information provided on this site is intended exclusively for educational and research purposes and should not be interpreted as medical guidance.
    • Research compounds, including MGF, are designed solely for laboratory investigation by qualified professionals and are not intended for human use or consumption.
    • The statements presented here have not been evaluated by the U.S. Food and Drug Administration, and the products discussed are not intended to diagnose, treat, cure, or prevent any disease.