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SS-31 (10mg)

SS-31 (10mg)

$65.00 USD
$65.00 USD
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Overview:

SS-31, also known as Elamipretide, is a synthetic tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH₂) that selectively targets the inner mitochondrial membrane, where it binds to cardiolipin a phospholipid crucial for mitochondrial integrity and function. SS-31 has been extensively studied for its antioxidant, cytoprotective, and mitochondria-restoring properties, making it a promising therapeutic candidate for mitochondrial myopathies, cardiomyopathies, retinal degenerative diseases, and age associated mitochondrial dysfunction.

Unlike general antioxidants, SS-31 localizes to mitochondria and prevents reactive oxygen species (ROS)-induced damage at the source, while simultaneously supporting ATP production and mitochondrial dynamics.

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PubChem Information

https://pubchem.ncbi.nlm.nih.gov/compound/11764719

  • Mechanism of Action:

    SS-31 functions through selective targeting of cardiolipin and stabilization of mitochondrial structure and function:

    • Binds to cardiolipin in the inner mitochondrial membrane, stabilizing cristae morphology and enhancing electron transport chain (ETC) efficiency
    • Reduces mitochondrial ROS generation, especially from complex I and III of the ETC
    • Prevents cytochrome c peroxidase activity, which is involved in oxidative damage and apoptosis
    • Enhances ATP production, improving mitochondrial bioenergetics and cell viability
    • Inhibits mitochondria-mediated apoptosis and promotes cell survival under stress conditions

  • Preclinical and Clinical Studies:

    • In mouse models of aging and mitochondrial disease, SS-31 improved mitochondrial respiration, exercise tolerance, and insulin sensitivity
    • In ischemia-reperfusion injury studies, SS-31 reduced cardiac infarct size and preserved left ventricular function
    • Shown to protect retinal photoreceptor cells and preserve vision in models of age-related macular degeneration (AMD)
    • Improved skeletal muscle strength and fatigue resistance in aged mice, partly through mitochondrial rejuvenation
    • Under investigation in clinical trials for Barth syndrome, primary mitochondrial myopathy, and heart failure with preserved ejection fraction (HFpEF)
    • May enhance mitochondrial dynamics and mitophagy, contributing to longevity and organ health in geriatric populations

  • Intended Use:

    • The information provided on this site is intended exclusively for educational and research purposes and should not be interpreted as medical guidance.
    • Research compounds, including SS-31, are designed solely for laboratory investigation by qualified professionals and are not intended for human use or consumption.
    • The statements presented here have not been evaluated by the U.S. Food and Drug Administration, and the products discussed are not intended to diagnose, treat, cure, or prevent any disease.